Ongoing Projects


The culturally adapted psychological intervention C-MAP utilizes problem solving components within a brief intervention that can be widely utilized in clinical practice. It has recently been shown that it is feasible to carry out large randomized control trials to evaluate psychological interventions in self-harm patients in low and middle income countries(14) and shows reduction in repetition of self-harm. Thus a strong rationale exists for the robust evaluation of C-MAP in order to clearly determine the clinical and cost effectiveness of this intervention.Read More


The At Risk Mental State (ARMS) describes individuals at high risk of developing schizophrenia or psychosis. The use of antipsychotics in this population is generally not supported because a large proportion of individuals with ARMS is not likely to develop psychosis. An alternative approach is where effective and relatively benign treatments are used within a clinically staged approach.


Bipolar disorder is a leading cause of disability worldwide. A high proportion of patients with bipolar disorder experience persistent depressive symptoms that do not respond to standard drug treatments. Recent evidence has suggested that anti-inflammatory treatment may reduce depressive symptoms. Minocycline is a tetracycline antibiotic with good CNS penetration that has been suggested to be effective as an adjunct drug in improving depressive symptoms. Celecoxib, a selective cyclooxygenase 2 (COX-2) inhibitor, has also shown promising results in the treatment of depressive symptoms. This is a multi-site, three-month, randomised, placebo controlled, double-blind factorial design trial of minocycline and/or celecoxib added to treatment as usual for the treatment of depressive symptoms in patients suffering from DSM-5 bipolar I or II disorder and To investigate whether the addition of Minocycline and/or celecoxib to treatment as usual (TAU) for 3 months in patients experiencing a depressive phase of bipolar disorder will lead to an improvement in depressive symptoms compared with TAU.   Read More


SHAHEEN is an innovative program to instill deep understanding of health issues amongst school going children and their parents. The main objective of SHAHEEN is to ensure children and adolescents have an increased awareness of health, mental health, and other well-being issues that should constitute an integral part of formal education.

Completed Projects


Learning Through Play (LTP) Plus is a low-literacy, sustainable program intended to provide parents with information on the healthy growth and development of their young children. The LTP research-based activities enhance children’s development while simultaneously promoting attachment security through building parents’ ability to read and be sensitive to their children’s cues and through active involvement in their children’s development. Plus the Thinking Healthy Program (THP) which adopts ‘here and now’ problem-solving approach. THP uses cognitive behavior therapy (CBT) techniques of active listening, changing negative thinking, and collaboration with the family.



A Randomised Double Blind Placebo Controlled 12 week trial of Methotrexate added to Treatment As Usual in Early Schizophrenia. Objective of this project is to test the prediction that addition of methotrexate (commonly used anti-inflammatory and immunosuppressive drug) to treatment as usual (TAU) for patients with early schizophrenia will result in improvement in positive and negative symptoms of schizophrenia, social and cognitive function. We are recruiting participants from 4 different centres in Karachi (Abbasi Shaheed hospital, Institute of Behavioural Science, Civil Hospital, and Karwan e Hyat). Trained researchers recruit the participants, assess them against inclusion criteria of the study, take consent from them, and randomize them after completion of detailed baseline assessment. We follow participants for 3 months.


In this double blind randomized controlled pilot trial the investigators aim to determine the efficacy of minocycline as an adjunct to treatment as usual in patients with major depressive disorder. The investigators hypothesize that the multiple neuro-protective effects of minocycline will lead to an improvement in depressive symptoms in participants that were given minocycline plus treatment as usual.

Future Projects


A national scale research study, designed to address the rise of British South Asian(BSA) women who experience post natal depression. An extension from Roshni and funded by National Institute of Health Research (NIHR) , ROSHNI- 2 is a multisite trial to compare Treatment as Usual (TAU) plus Positive Health Programme (PHP) versus TAU for British South Asian (BSA) women with postnatal depression to determine the clinical & cost-effectiveness. Study areas include Northwest, Yorkshire, East Midlands, Glasgow & London. We aim to investigate the effectiveness of The Positive Health Programme by comparing British South Asian(BSA) women included in our programme( alongside routine treatment) to women receiving treatments through their usual health care service.Psychological therapies are effective in treating Postnatal Depression ROSHNI-2 incorporates Cognitive Behaviour Therapy (CBT) into a culturally adapted intervention—The Positive Health Programme (PHP).Eligible patients, will attend local centres to receive 12 sessions that focus on promoting a healthier life-style and building confidence., self-esteem and problem solving skills.The trial starts in July 2016 and will be conducted over 4 years. Recruitment of participants will start towards the end of 2016

We eat elephants(In Process)

Mental Health has been highlighted as primary issues in Global Mental Health in low and middle income countries. Poor mental health leads children to low educational achievements, substance abuse , violence and poor reproductive and sexual health. In this project we will train teachers in this intervention called we eat elephant. This intervention would involve more of teachers training using the video and audio modules along with self-help resources of the intervention. The teachers would be trained by qualified psychologist to deliver interventions to the participating students.



Cognitive Behavior Therapy (CBT) has been found to be beneficial in the treatment of positive symptoms and negative symptoms of psychosis. Adapted CBT was found to be effective in reducing symptoms of depression in a pilot trial. We have adapted CBT for psychosis using the methodology, which has been successfully employed in adapting CBT for depression in Pakistan. This study is intended to assess the feasibility of adapted CBT in Pakistan.


The role of the family in the community is more important and supporting with people who suffer long-term mental illness۔ Family Intervention for psychosis is a collaborative approach aimed at working in partnership with both individuals and their families. Through this approach builds upon existing strengths and explores solutions which enable families to effectively deal with the difficulties they may face as a result of the illness.


Evidence suggest that the psychosocial interventions to enhance mood stability of bipolar patients in the long term. Culturally adapted psychosocial intervention with routine pharmacological treatment was acceptable for bipolar disorder patients and was helpful in enhance the mood stability.



The objective of the study is to train TBAs and through them intervention is provided to depressed mothers. TBAs are the persons who have first interaction with mother after the child birth so they can guide easily to them.


In this project we are aiming to develop and provide a comprehensive assessment tool for memory loss for local populations.


This project aims to investigate the prevalence of depression in primary care patients with chronic heart disease in urban Pakistan.